Ultimos Posts 1. 19/02/2008 08:52 - Regulation of Replication Fork Progression Through Histone Supply and Demand This work shows that the replacement of histones is coordinated with the fork progression during DNA replication. After finding that Asf1 , the H3-H4 chaperone, co- purified with the putative helicase MCM2 -7 in HeLa cells, the question then was if problems during replication could be the consequence of abnormal chromatin unwinding. This was confirmed by following the cell cycle pr... 2. 15/02/2008 08:48 - The histone deacetylase inhibitor valproic acid enhances acquisition, extinction, and reconsolidation of conditioned fear Histone modifications have been found to contribute with certain brain phenomena like memory and behavior, and in this respect, some HDAC inhibitors have been shown to enhance long- term memory, which makes them interesting candidates for treatment of cognitive disorders, particularly phobias, but also for other behavior alterations, like anxiety disorders. In this paper, authors r... 3. 09/01/2008 11:52 - The Obesity-Associated FTO Gene Encodes a 2-Oxoglutarate-Dependent Nucleic Acid Demethylase Studies have revealed an association between variants of the first intron of the human FTO gene and obesity. Computational analyses predict that the protein product of FTO contains a 2-oxoglutarate oxygenase (2OG) fold, and these oxygenases have been found to be involved in diverse cellular processes, ranging from DNA repair to histone demethylation. Here authors characterized a re... 4. 23/10/2007 05:09 - The role of site accessibility in microRNA target recognition Currently, most microRNA predictors perform so poorly that it was easy to assume that secondary structure formation has a more important role in target recognition, instead of relying in sequence complementarity alone. To further evaluate this hypothesis, this group previously reported the development of a quantitative (luminiscent) assay for measuring repression by microRNAs , and... 5. 11/10/2007 09:42 - Periodic epi-organization of the yeast genome revealed by the distribution of promoter sites Some studies of the chromatin structure have revealed that chromosomes are compartmentalized in some areas of the nucleus, as is the case for nucleoli; other similar phenomena of regional specialization is the case of the centrosomal and nucleolar polarity, and it is very likely that these spatial arrangements must have an influence over gene expression regulation. In this paper, K... |
